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Kana dihydrotanshinone ini ndikauraya Helicobacter pylori, haingogone chete kuparadza biofilm, asi zvakare kuuraya hutachiona hwakanamatira kune biofilm, iyo inoita basa "kudzura" Helicobacter pylori.

Bi Hongkai, Purofesa, Chikoro cheMishonga Yekutanga, Nanjing Medical University

Idzo dhata dzazvino dzekenza dzepasirese dzinoratidza kuti pakati pevane mamirioni 4,577 emukenza nyowani muChina gore rega rega, mazana mana mazana masere ezviuru mazana masere ezviitiko zvegomarara repamuviri, rinoverengera 10.8%, zviri pakati pevatatu vepamusoro. MuChina ine huwandu hwakanyanya hwegomarara repamuviri, huwandu hwehutachiona hweHelicobacter pylori hwakakwira kusvika pa50%, uye dambudziko rekurwisa mabhakitiriya riri kuramba richiwedzera uye zvichikonzera kuramba kuchiderera padanho rekuparadza.
Munguva pfupi yapfuura, timu yaPurofesa Bi Hongkai, Chikoro cheMishonga Yekutanga, Nanjing Medical University, yakabudirira kuongorora mushandi mutsva wemushonga weHelicobacter pylori-Dihydrotanshinone I. - Helicobacter pylori biofilm, kuchengetedzeka uye kuramba kurwisa, nezvimwewo, uye inotarisirwa kupinda mukutsvagurudza kwepamberi seanopokana- Helicobacter pylori mukwikwidzi wemishonga. Mhedzisiro yacho yakaburitswa pamhepo mune ane chiremera epasi rose antimicrobial magazini "Antimicrobial Agents uye Chemotherapy".

Yekutanga kurapwa kutadza chiyero chetsika kurapwa kuri nezve 10%

Pasi peiyo microscope, kureba kwacho kungori ma2,5 micrometer kusvika ku4 micrometer, uye upamhi ihwo chete 0.5 micrometer kusvika 1 micrometer. Helicobacter pylori, hutachiona hwakakombama hwemweya "hunoparadzira mazino nekutamba nzwara", haigone chete kukonzera gastricitis yakaoma uye isingaperi, gastric uye duodenal ulcers uye lymphatics. Zvirwere zvakadai sekuwedzera gastric lymphoma zvakare zvine hukama nekenza yemudumbu, gomarara rechiropa, uye chirwere cheshuga.

Iyo katatu uye katatu kurapa ine maviri maantibioti anowanzo shandiswa munyika yangu kurapa Helicobacter pylori, asi echinyakare maitiro ekurapa haakwanise kubvisa Helicobacter pylori.

“Kukundikana kwehutano hwekutanga kurapwa kwechinyakare kunosvika gumi muzana. Vamwe varwere vanozoita manyoka kana gastrointestinal flora kusagadzikana. Zvimwe zvinopesana ne penicillin, uye kune mashoma maantibayoti aunosarudza kubva. " Bi Hongkai akati: “Mabhakitiriya anoshingirira kumamwe maantibayoti, uye anozoshingirirawo kumamwe maantibayoti, uye nemushonga wacho unogona kusiyanawo nenzira dzakasiyana. Hutachiona hunopararira huchienda kune humwe kuburikidza nemajini asingapfuurwi nemishonga, izvo zvinoita kuti utachiona husabatira mishonga. ”

Kana Helicobacter pylori ichirwisa kupinda kwevavengi, nehungwaru ichaumba biofilm "chivharo chekudzivirira" pachayo, uye iyo biofilm ichave nemushonga wemishonga inorwisa mabhakitiriya, zvichikonzera kuwedzera kurwisa kwaHelicobacter pylori, ichikanganisa maitiro ekurapa uye kudzikisira iyo Rate yekurapa.

Salvia miltiorrhiza kubvisa sero kuyedza kunogona kudzvinyirira akawanda-asingadziviriri maronda

Muna 1994, World Health Organisation yakaratidza Helicobacter pylori seClass I carcinogen nekuti inoita chinzvimbo chinotungamira mukuitika nekusimudzira kenza yemudumbu. Maitiro ekubvisa sei ichi chinouraya chinouraya? Muna 2017, timu yaBi Hongkai yakaita budiriro kuburikidza neyekutanga kuyedza-Danshen.

Danshen ndeimwe yemishonga yechinyakare inonyanyo shandiswa yechiChinese yekusimudzira kutenderera kweropa uye kubvisa stasis yeropa. Mafuta ayo-akasarudzika mafuta ndeaya tanshinone macomputer, anosanganisira anopfuura makumi matatu mamonamu akadai tanshinone I, dihydrotanshinone, tanshinone IIA, uye cryptotanshinone. Tanshinone macompound ane akasiyana siyana emakemikari mhedzisiro, senge anti-cancer, anti-positive mabhakitiriya, anti-kupisa, esrogen-senge chiitiko uye yemoyo kudzivirirwa, nezvimwewo, asi iyo anti-Helicobacter pylori mhedzisiro haina kutaurwa.

“Kare, takavheneka vanodarika chiuru chemishonga yechiChinese padanho rechitokisi, tikazopedzisira taona kuti dihydrotanshinone I monomer muDanshen yaive nemhedzisiro yekuuraya Helicobacter pylori. Pakuita masero ekuyedza, takaona kuti apo kusangana kwe dihydrotanshinone kwandaishandiswa Kana iri 0.125 μg / ml-0.5 μg / ml, inogona kudzivisa kukura kweakawanda maHelicobacter pylori strains, kusanganisira maantibayoti-anonzwisisa uye akawanda-asinganetsi mishonga . ” Bi Hongkai akataura kuti dihydrotanshinone ini ndinoshandawo kwazvo kurwisa Helicobacter pylori mune biofilms. Hunhu hwakanaka hwekuuraya, uye Helicobacter pylori haana kukudziridza kuramba dihydrotanshinone I panguva yekuenderera mberi.

Chinhu chikuru chakashamisa ndechekuti "Kana dihydrotanshinone ini ndikauraya Helicobacter pylori, haingogone chete kuparadza biofilm, asi zvakare kuuraya hutachiona hwakabatana neiyo biofilm, iyo inoita basa mu'kutora midzi 'kweHelicobacter pylori. “Bi Hongkai akaunza.

Inogona here Dihydrotanshinone ini kuporesa Helicobacter pylori?

Kuti mhedzisiro yekuedza iwedzere kunyatsoitika, timu yaBi Hongkai yakaitawo zviyedzo zvekuongorora mumakonzo kuti vaonezve kuuraya kwe dihydrotanshinone I pa Helicobacter pylori.

Bi Hongkai akaunza kuti mukuyedza, mavhiki maviri mbeva dzakatapukirwa neHelicobacter pylori, vaongorori vakavaparadzanisa muzvikwata zvitatu, rinova iro rakabatana boka revatungamiriri omeprazole uye dihydrotanshinone I, iro rakajairika katatu regimen management boka, uye phosphoric acid In iyo buffer control group, mbeva dzakapihwa mushonga kamwe pazuva pazuva kwemazuva matatu akateedzana.

"Mhedzisiro yekuongorora inoratidza kuti boka rakabatana revatungamiriri omeprazole uye dihydrotanshinone I ine hunyanzvi hwepamusoro mukuuraya Helicobacter pylori kupfuura iro rakajairika katatu regimen boka." Bi Hongkai akadaro, zvinoreva kuti mumakonzo, dihydrotanshinone ini ndine yakanyanya kuuraya kugona kupfuura mishonga yechinyakare.

Dihydrotanshinone ini ndinopinda rini mudzimba dzevanhuwo zvavo? Bi Hongkai akasimbisa kuti Danshen haigone kushandiswa zvakananga kudzivirira uye kurapa hutachiona hweHelicobacter pylori, uye monomer yaro dihydrotanshinone ini ndichiri kure nekugadzirwa semushonga unogona kushandiswa mukiriniki. Akataura kuti danho rinotevera richaramba richidzidza mashandiro e dihydrotanshinone I, nekuvandudza pharmacology uye toxicology ye dihydrotanshinone I kurwisa Helicobacter pylori. “Mugwagwa uri mberi uchakareba. Ndinovimba makambani anokwanisa kutora chikamu mukutsvagurudza kwepamberi kwekiriniki uye kuenderera mberi nekutsvagurudza kubatsira varwere vazhinji vanezvirwere zvemudumbu. ”